Buy Cortagen (20mg)

Cortagen Peptide Description

Cortagen (Ala-Glu-Asp-Pro) is a tetrapeptide member of the Khavinson peptide bioregulator family, a group of short peptides typically consisting of 2-4 amino acids. These peptides are known for their powerful bioregulatory effects and their ability to influence gene expression in tissue-specific ways. Cortagen shows significant neuronoprotective and regenerative properties, particularly in the context of nerve injury, and it may also have implications for cardiovascular health.

Peptide Information

Cortagen Structure

Source: PepDraw

Product Usage:

This PRODUCT IS INTENDED AS A RESEARCH CHEMICAL ONLY. This designation allows the use of research chemicals strictly for in vitro testing and laboratory experimentation only. All product information available on this website is for educational purposes only.  This product should only be handled by licensed, qualified professionals. This product is not a drug, food, or cosmetic and may not be misbranded, misused or mislabeled as a drug.

Cortagen Research

Cortagen exhibits promising neuronoprotective and nerve regeneration properties, with potential applications in neurotrophic therapies. Its ability to modulate gene expression in the heart also suggests broader therapeutic implications, particularly in cardiovascular health. However, its effects on immunity and hemostasis appear limited compared to similar peptides. Further research is needed to fully understand the mechanisms and potential clinical applications of cortagen.

Neuronoprotective Effects

Cortagen has been shown to exhibit neuronoprotective properties. Studies have demonstrated that cortagen can modulate neuronal activity by affecting the resting potential and action potential of neurons. Specifically, cortagen hyperpolarizes neurons and reduces their spontaneous activity, indicating its activating and neuronoprotective action.¹

Role in Nerve Regeneration

Cortagen has been investigated for its role in nerve regeneration, particularly in the context of peripheral nerve injuries. Research involving rat models has shown that cortagen can stimulate the growth of nerve fibers during the initial stages of regeneration. However, its effects on the conductivity of regenerating nerve fibers were not significant, as measured by compound action potentials. The peptide did not notably affect the conduction velocity of action potentials through the suture site of injured nerves, suggesting that its primary benefits may lie in the early stages of nerve repair.²

Gene Expression and Cardiovascular Effects

Cortagen has also been studied for its impact on gene expression, particularly in the heart. Microarray analyses have revealed that cortagen can significantly alter the expression of numerous genes in the heart, which may contribute to its therapeutic effects. These changes in gene expression suggest potential benefits in cardiovascular and cerebrovascular health, although the specific mechanisms remain to be fully elucidated.³

Immunity and Hemostasis

In studies involving hypophysectomized chickens and older birds, cortagen did not significantly affect parameters related to erythrocytes, immunity, and hemostasis. This contrasts with another tetrapeptide, epithalon, which was effective in eliminating shifts in these parameters. The difference in terminal amino acids between cortagen and epithalon may account for their differing effects on these physiological systems.⁴

References

1. Shabanov, P., & Vislobokov, A. (2013). Neuronoprotective action of cortexin andcortagen. Reviews on Clinical Pharmacology and Drug Therapy, 11, 17-25. https://doi.org/10.17816/RCF11217-25.
2. Kolosova, L., Moiseeva, A., Turchaninova, L., Malinin, V., Polyakov, E., Nozdrachev, A., & Khavinson, V. (2002). The Delayed Effect of Cortagen on the Restoration of Injured Nerve Function. Doklady Biological Sciences, 384, 183-184. https://doi.org/10.1023/A:1016098302564.
3. Anisimov, S., Khavinson, V., & Anisimov, V. (2004). Elucidation of the effect of brain cortex tetrapeptide Cortagen on gene expression in mouse heart by microarray.. Neuro endocrinology letters, 25 1-2, 87-93 . https://pubmed.ncbi.nlm.nih.gov/15159690/
4. Kuznik, B., Pateiuk, A., Baranchugova, L., & Rusaeva, N. (2008). [Effects of epithalon and cortagene on immunity and hemostasis in neonatally hypophysectomized chicken and old birds]. Advances in gerontology = Uspekhi gerontologii, 21 3, 372-81. https://pubmed.ncbi.nlm.nih.gov/19432169/

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This content is provided strictly for research purposes and does not constitute an endorsement or recommendation for the non-laboratory application or improper handling of peptides designed for research. The information, including discussions about specific peptides and their researched benefits, is presented for informational purposes only and must not be construed as health, clinical, or legal guidance, nor an encouragement for non-research use in humans. Peptides described here are solely for use in structured scientific study by authorized individuals. We advise consulting with research experts, medical practitioners, or legal counsel prior to any decisions about obtaining or utilizing these peptides. The expectation of responsible, ethical utilization of this information for legitimate investigative and scholarly objectives is paramount. This notice is dynamic and governs all provided content on research peptides. . .