Buy NAD+ / MOTS-c / 5-Amino-1MQ Blend – 120mg (100mg / 10mg / 10mg)

NAD+ / MOTS-c / 5-Amino-1MQ Peptide Blend Description

The BioLongevity Labs NAD+/MOTS-c/5-Amino-1MQ Blend unites three distinct compounds that converge on cellular energy, mitochondrial function, and metabolic regulation:

• NAD+ (100 mg) replenishes the central redox cofactor required for metabolism, DNA repair, and sirtuin activation [1][2][3].
• MOTS-c (10 mg) is a mitochondria-derived peptide that activates AMPK, regulates nuclear gene expression under metabolic stress, and enhances insulin sensitivity [4][5][6].
• 5-Amino-1MQ (10 mg) inhibits NNMT, raising NAD+ levels while modulating histone methylation and fat metabolism pathways [7][8][9].

Together, their mechanisms are designed to:

• Enhance mitochondrial and cellular energy balance by restoring NAD+ pools and activating AMPK [1][4][7].
• Improve metabolic health by reducing adiposity, sustaining muscle function, and optimizing glucose regulation [2][5][8].
• Support cognitive and longevity research through effects on neuroinflammation, oxidative stress, and cellular senescence [3][6][9].

Peptide Structures

NAD+ (Nicotinamide Adenine Dinucleotide)

• Molecular Formula: C₂₁H₂₇N₇O₁₄P₂
• Molecular Weight: 663.43 g/mol
• PubChem CID: 925
• CAS Number: 53-84-9
• Synonyms: β-Nicotinamide adenine dinucleotide, DPN, Coenzyme I, Diphosphopyridine nucleotide

MOTS-c (Mitochondrial Open Reading Frame of the 12S rRNA-c)

• Sequence: Met-Arg-Trp-Gln-Glu-Met-Gly-Tyr-Ile-Phe-Tyr-Pro-Arg-Lys-Leu-Arg
• Molecular Formula: C₁₀₁H₁₅₂N₂₈O₂₂S₂
• Molecular Weight: 2174.6 g/mol
• PubChem SID: 255386757
• CAS Number: 1627580-64-6
• Synonyms: Human MOTS-c, UNII-A5CV6JFB78, MOTS-c trifluoroacetate salt

5-Amino-1MQ (5-Amino-1-methylquinolinium)

• Molecular Formula: C₁₀H₁₁N₂
• Molecular Weight: 159.21 g/mol
• PubChem CID: 950107
• CAS Number: —
• Synonyms: 5-amino-1-methylquinolinium, SCHEMBL6403148, CHEMBL4116828, ZMJBCEIHNOWCMC-UHFFFAOYSA-O, STL196667

This synergistic triad provides a unique investigational platform for metabolism, neuroprotection, and healthy aging research.

Blend Structure

Research Areas

• Cellular Energy & Mitochondrial Function
• Metabolic Regulation & Obesity Research
• Muscle Preservation & Physical Performance
• Neuroprotection & Cognitive Function
• Longevity & Anti-Aging Mechanisms
• Preclinical Cancer Research

NAD+/MOTS-c/5-Amino-1MQ Peptide Blend Research

Cellular Energy & Mitochondrial Function

NAD+ plays a vital role in redox reactions and sirtuin activation. Restoring NAD+ levels in aging and metabolic stress models improved glucose tolerance, mitochondrial function, and overall health [1]. MOTS-c translocates to the nucleus during metabolic stress to regulate antioxidant and glucose metabolism genes via AMPK activation [4]. 5-Amino-1MQ further boosts NAD+ by inhibiting NNMT, enhancing redox balance and mitochondrial efficiency [7].

Metabolic Regulation & Obesity Research

NAD+ depletion contributes to obesity and metabolic disorders; replenishment strategies improve metabolic homeostasis [2]. MOTS-c prevents diet-induced obesity and insulin resistance by improving glucose utilization and maintaining adipose homeostasis [5]. 5-Amino-1MQ reduces white adipose tissue and body weight in preclinical obesity models without affecting appetite, highlighting its direct metabolic actions [8].

Neuroprotection & Longevity

NAD+ enhancement has been shown to reduce neuroinflammation and improve cognition in models of neurodegeneration [3]. MOTS-c enhances memory formation and protects against neuroinflammation, with benefits observed in Alzheimer’s and metabolic dysfunction models [6]. 5-Amino-1MQ alters histone methylation and metabolic programs in cancer and aging models, representing a promising target for longevity and oncology research [9].

References

NAD+

1. Rajman L, et al. Cell Metab. 2018. Therapeutic potential of NAD-boosting molecules in vivo. https://doi.org/10.1016/j.cmet.2018.02.011
2. Okabe K, et al. J Biomed Sci. 2019. Altered NAD+ metabolism in metabolic disorders. https://doi.org/10.1186/s12929-019-0527-8
3. Zhao Y, et al. J Neuroinflammation. 2021. NAD+ improves cognition via Sirt1/PGC-1α. https://doi.org/10.1186/s12974-021-02250-8

MOTS-c

4. Kim K, et al. Cell Metab. 2018. MOTS-c translocates to the nucleus during metabolic stress. https://doi.org/10.1016/j.cmet.2018.06.008
5. Lu H, et al. J Mol Med. 2019. MOTS-c regulates adipose homeostasis and prevents metabolic dysfunction. https://doi.org/10.1007/s00109-018-01738-w
6. Lee C, et al. Cell Metab. 2015. MOTS-c promotes metabolic homeostasis and reduces obesity/insulin resistance. https://doi.org/10.1016/j.cmet.2015.02.009

5-Amino-1MQ

7. Conlon N, Ford D. Biochem Pharmacol. 2022. Systems approach to NAD+ restoration via NNMT inhibition. https://doi.org/10.1016/j.bcp.2022.114946
8. Liu J, et al. Biomed Res Int. 2021. NNMT inhibition reduces obesity and diabetes risk. https://doi.org/10.1155/2021/9924314
9. Li X, et al. Front Oncol. 2022. NNMT as a biomarker and target in cancer. https://doi.org/10.3389/fonc.2022.894744

Note: This product is supplied strictly for investigational research use only. It is not approved or intended for diagnostic, therapeutic, or in vivo applications in humans or animals.

NAD+ / MOTS-c / 5-Amino-1MQ 

NAD+,MOTS-C/5-AMINO-1MQ

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