Buy N-Acetyl Selank Amidate (20mg)

N-Acetyl Selank Amidate Product Description

Selank is a heptapeptide (Thr-Lys-Pro-Arg-Pro-Gly-Pro) with significant anxiolytic, cognitive-enhancing, and immunomodulatory effects. Its ability to modulate the GABAergic system and influence gene expression underlies its therapeutic research potential, particularly in managing anxiety and stress-related conditions.

N-Acetyl Selank is a modified version of Selank designed to improve its pharmacological properties. The addition of an acetyl group at the N-terminus enhances its stability, potency, and ability to cross the blood-brain barrier.

Peptide Information

N-Acetyl Selank Peptide Structure

Source PubChem

Product Usage:

This PRODUCT IS INTENDED AS A RESEARCH CHEMICAL ONLY. This designation allows the use of research chemicals strictly for in vitro testing and laboratory experimentation only. All product information available on this website is for educational purposes only.  This product should only be handled by licensed, qualified professionals. This product is not a drug, food, or cosmetic and may not be misbranded, misused or mislabeled as a drug.

N-Acetyl Selank Research

Selank is a multifaceted peptide with significant potential in treating anxiety, cognitive impairments, and stress-related physiological changes. Its ability to modulate the GABAergic system, enhance cognitive function, and exert immunomodulatory effects positions it as a versatile therapeutic agent.

Anxiolytic and Cognitive Effects

Selank has demonstrated significant anxiolytic properties, comparable to classical benzodiazepines, without the associated side effects such as dependence and memory impairment¹. It has been shown to reduce anxiety in conditions of chronic stress and improve cognitive functions, such as memory and attention, particularly in the context of ethanol-induced impairments. The peptide’s ability to regulate brain-derived neurotrophic factor (BDNF) content in the hippocampus and prefrontal cortex is thought to contribute to its cognitive-enhancing effects².

Immunomodulatory and Antiviral Properties

Beyond its neurological effects, Selank also exhibits immunomodulatory and antiviral properties. It can significantly alter the expression of genes related to chemokines, cytokines, and their receptors, suggesting a role in immune response modulation³. These properties make Selank a promising candidate for therapeutic applications beyond anxiety and cognitive disorders.

Stress Mitigation and Physiological Effects

Selank has been shown to mitigate stress-induced physiological changes. In animal models, it reduces stress-related morphological changes in organs such as the liver and colon, indicating its potential to alleviate stress-induced damage. These effects are likely due to its multifunctional biological activity, which includes reducing corticosterone levels and promoting adaptation to stress⁴.

References

1. Vyunova, T., Andreeva, L., Shevchenko, K., & Myasoedov, N. (2018). Peptide-based Anxiolytics: The Molecular Aspects of Heptapeptide Selank Biological Activity.. Protein and peptide letters, 25 10, 914-923 . https://doi.org/10.2174/0929866525666180925144642.
2. Kolik, L., Nadorova, A., Antipova, T., Kruglov, S., Kudrin, V., & Durnev, A. (2019). Selank, Peptide Analogue of Tuftsin, Protects Against Ethanol-Induced Memory Impairment by Regulating of BDNF Content in the Hippocampus and Prefrontal Cortex in Rats. Bulletin of Experimental Biology and Medicine, 167, 641 – 644. https://doi.org/10.1007/s10517-019-04588-9.
3. Kolomin, T., Mikhalskaia, P., & Sedelnikova, A. (2023). Changes in Expression of Chemokines, Cytokines and their Receptors under the Action of Selank and its Fragments. Journal of Clinical Physiology and Pathology. https://doi.org/10.59315/jiscpp.2023-2-2.16-18.
4. Mukhina, A., Mishina, E., Bobyntsev, I., Medvedeva, O., Svishcheva, M., Kalutskiĭ, P., Andreeva, L., & Myasoedov, N. (2020). Morphological Changes in the Large Intestine of Rats Subjected to Chronic Restraint Stress and Treated with Selank. Bulletin of Experimental Biology and Medicine, 169, 281 – 285. https://doi.org/10.1007/s10517-020-04868-9.

N-Acetyl-Selank Amidate (11233)

N-ACETYL SELANK AMIDATE (251444)

NA_Selank(10743)

Endotoxin N-AcetylSelankAmidate

NASA(10183)

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Disclaimer: For Research Purposes Only

This content is provided strictly for research purposes and does not constitute an endorsement or recommendation for the non-laboratory application or improper handling of peptides designed for research. The information, including discussions about specific peptides and their researched benefits, is presented for informational purposes only and must not be construed as health, clinical, or legal guidance, nor an encouragement for non-research use in humans. Peptides described here are solely for use in structured scientific study by authorized individuals. We advise consulting with research experts, medical practitioners, or legal counsel prior to any decisions about obtaining or utilizing these peptides. The expectation of responsible, ethical utilization of this information for legitimate investigative and scholarly objectives is paramount. This notice is dynamic and governs all provided content on research peptides. . .